Online weight loss programs · GLP-1 treatment

Your Health, Your Plan: Individualized Weight Loss That Works for You.

Physician-guided GLP-1 weight loss with Sema or Tirzep, prescribed online by board-certified physicians and shipped to your door in discreet packaging.

Sema (GLP-1)Tirzep (GLP-1/GIP)
Board-certified physicians Not charged if you’re not a candidate Discreet delivery

Diverse group of smiling men and women walking outdoors, showing SimpleFixRx online weight loss is for everyone

One questionnaire. A plan made for you.Reviewed by a licensed physician

100% onlineHealth questionnaire from home, no waiting rooms

Physician-reviewedBoard-certified physicians create your plan

No charge if not a candidateYou only pay if you’re prescribed

LegitScript certifiedVerify our approval
GLP-1 weight loss treatment options

Multiple ways to lose weight, one simple process.

Every body is different. That’s why our physicians offer more than one GLP-1 weight loss medication, each tailored to your goals, lifestyle, and budget.

SimpleFixRx GLP-1 Sema injection vial for medical weight loss

GLP-1

Sema Weight Loss

A once-weekly GLP-1 injection that helps curb appetite, slow digestion, and keep you feeling full longer, so eating less feels easier.

  • Once-weekly injection
  • Dose increased gradually
  • Individualized by your physician

Start with Sema

SimpleFixRx GLP-1/GIP Tirzep injection vial for medical weight loss

GLP-1 / GIP

Tirzep Weight Loss

A once-weekly dual-action injection that works on two hunger and blood-sugar hormones, GLP-1 and GIP, for people who want a next-generation option.

  • Dual GLP-1/GIP action
  • Once-weekly injection
  • Step-by-step dosing plan

Start with Tirzep

Prescription required. Not everyone qualifies. Your physician decides which medication, if any, is right for you. Important Safety Information

Smiling board-certified physician at his desk reviewing a patient weight loss plan

Let Your Physician Decide

Not sure whether Sema or Tirzep fits you better? Complete one questionnaire and your physician will recommend the right medication and dose for your health history.

  • One health questionnaire
  • Physician recommendation
  • Switch options as you progress

Physician-guided medical weight loss

Same trusted support. Same science-backed results.

Now with even more ways to make it work for you. We know that every body is different, which is why our team offers multiple treatment options, each tailored to your goals, lifestyle, and budget.

Whether you’re just getting started or continuing treatment, we’re here to make it simple, effective, and stress-free.

Individualized dosing.Your physician starts low and adjusts your Sema or Tirzep dose over time.

Ongoing support.Questions about side effects or your next dose? Text our team anytime.

Continuing treatment?Already on a GLP-1? Tell us in your questionnaire so your physician can plan your next step.

Man on his sofa during a telehealth weight loss visit with a SimpleFixRx physician on a tablet
How it works

Online weight loss in three simple steps.

No pressure. No complicated hoops. Just real help, from real people who care.

  1. 01

    Complete the health questionnaire

    Answer a secure online questionnaire about your health, weight, and goals. It only takes a few minutes.

  2. 02

    Physician review

    Board-certified physicians will review and, if you are a candidate, create an individualized plan for you. You will not be charged if you are not a candidate.

  3. 03

    Delivered to your door

    The medication will be mailed to you in discreet packaging. You will be on your way to being the best you.

Start the Health Questionnaire

Sema vs. Tirzep

Which GLP-1 weight loss medication is right for me?

Both are once-weekly prescription injections used for medical weight loss. Here’s a simple side-by-side look. Your physician makes the final recommendation based on your health history.

Compare
SemaGLP-1
TirzepGLP-1 / GIP
How it works
SemaMimics GLP-1, a natural gut hormone that signals fullness and helps regulate blood sugar
TirzepActs on two hormones, GLP-1 and GIP, for dual-action appetite and blood-sugar support
How it’s taken
SemaOnce-weekly injection under the skin
TirzepOnce-weekly injection under the skin
Dosing
SemaStarts at a low dose and increases gradually as your body adjusts
TirzepStarts at a low dose and increases in steps as your body adjusts
Common side effects
SemaNausea, diarrhea, constipation, vomiting, stomach discomfort
TirzepNausea, diarrhea, constipation, vomiting, stomach discomfort
Often a fit for
SemaPeople starting GLP-1 weight loss for the first time
TirzepPeople who want a dual-action option or who plateaued on a GLP-1
Prescription
SemaRequired, after an online physician review
TirzepRequired, after an online physician review

Not sure which fits? Your physician recommends the medication and dose after reviewing your health history.

Find Out Which One Fits You

SimpleFix weight loss patient before treatment, sitting on a couch holding her grandchild
Before 208 lbs
SimpleFix weight loss patient after treatment, smiling and holding her grandchild
After 182 lbs

Real SimpleFix results

Before and after, in her own words.

26 lbslost on her SimpleFix
weight loss program

A SimpleFix weight loss patient shares her journey, from 208 lbs to 182 lbs, and feeling amazing. Her physician-guided plan paired a once-weekly GLP-1 with small, steady changes to how she eats and moves.

Individual results vary and are not guaranteed. Weight loss depends on your health, dose, diet, and activity.

Start Your Journey

Dr. Sunil Kurup, MD, physician at SimpleFixRx

Physician

Dr. Sunil Kurup, MD

Background in Family Practice and Sports Medicine, with a focus on weight management, aesthetics and regenerative medicine.

Professional background

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FAQ

Questions about online weight loss.

Have something else on your mind? Text us any time — our team is happy to help.

(682) 245-2031

What is the SimpleFixRx online weight loss program?

SimpleFixRx connects patients with licensed providers for evaluation of weight-management treatment. If medication is appropriate, the provider discusses treatment options, benefits, risks and follow-up. Your provider determines the evaluation and follow-up you need based on your health history, treatment and the requirements where you are physically located. A live video or phone visit, testing or an in-person examination may be required. Completing a questionnaire or making a payment does not guarantee a prescription.

What is the difference between Sema and Tirzep?

Sema and Tirzep refer to different prescription medications with different active ingredients. They are not interchangeable, and dose instructions must not be transferred from one product or concentration to another. Your clinician will identify the exact medication, whether it is FDA-approved or compounded, and its intended use before treatment. See the side-by-side comparison.

Do I need a prescription for GLP-1 weight loss medication?

Yes. GLP-1 prescription treatment requires an appropriate evaluation and a valid prescription from an authorized clinician. Not everyone qualifies. Your provider determines the evaluation and follow-up you need based on your health history, treatment and the requirements where you are physically located. A live video or phone visit, testing or an in-person examination may be required. Completing a questionnaire or making a payment does not guarantee a prescription.

Will I be charged if I don’t qualify?

Eligibility is decided by an independent licensed provider, not by payment. Review the program’s checkout terms for any consultation fees, payment authorizations and refund conditions before submitting an order. If treatment is not prescribed, contact our team to confirm how those terms apply to your transaction.

How fast will I lose weight?

There is no guaranteed amount or speed of weight loss. Outcomes depend on the individual, the specific medication and treatment plan, and other health and lifestyle factors. Your clinician will discuss realistic expectations and monitor your response; published results for one product do not establish results for another.

What are the common side effects?

Side effects vary by medication and can include nausea, vomiting, diarrhea, constipation and abdominal discomfort. Serious risks are also possible. Read the information supplied for your exact prescription and discuss your medical history, other medicines and pregnancy plans with your clinician. Contact your clinician promptly about concerning symptoms, and seek emergency care for severe symptoms.

I’m already on a GLP-1. Can I continue treatment with SimpleFixRx?

You may request a treatment review. Share the exact medication, formulation, concentration, dose, last dose date, prescribing records and any side effects. A clinician decides whether continuation, a change or an in-person assessment is appropriate. Do not switch products or reuse dose-conversion instructions without your clinician’s direction.

How is my medication shipped?

Shipping is arranged only after any required prescription is approved and the dispensing pharmacy completes its review. Availability, carrier and delivery timing depend on the medication, pharmacy and destination. Follow your pharmacy’s storage instructions and contact the pharmacy before using medication that arrives damaged or outside its storage requirements.

Are compounded GLP-1 medications FDA-approved?

Compounded medications are not FDA-approved. FDA does not review them for safety, effectiveness or quality before marketing, and they are not FDA-approved generic equivalents of branded medicines. A compounded medication should be considered only when a patient’s medical needs cannot be met by an FDA-approved product. Read the FDA’s information on unapproved GLP-1 drugs.

Where can I find more answers?

Visit our FAQ page for general questions, or learn about SimpleFixRx and our physicians. Text (682) 245-2031 to reach our team or request a conversation with your provider. For personal treatment advice, speak with your prescribing clinician rather than relying on general website information.

Important Safety Information: Sema and Tirzep are prescription medications and are not right for everyone. They carry a boxed warning about the possible risk of thyroid C-cell tumors. Do not use them if you or a family member have had medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Read the full Important Safety Information.

Ready when you are

Start your weight loss journey today.

Complete the health questionnaire in minutes. If you’re a candidate, a board-certified physician creates your individualized Sema or Tirzep plan. You won’t be charged if you’re not a candidate.

Helpful links

Already a patient?

Log in to your patient portal, or explore more about SimpleFixRx.

Want to see real patient results?Join our private patient group on Facebook for more stories, tips and support.

Join the private group ↗

Three smiling women in athletic wear, representing healthy habits with GLP-1 weight loss
Medication + habits = lasting results

GLP-1 makes healthy habits easier to keep.

Sema and Tirzep quiet food noise and help you feel full sooner. Pair them with protein-rich meals, water, and daily movement to protect muscle and keep the weight off.

  • Protein-rich meals
  • Plenty of water
  • Daily movement
  • Steady, sustainable changes

Medical leadership

Care led by experienced physicians.

Meet our full physician team

Dr. Garrett Garner, MD, FACOG, Head Medical Director at SimpleFixRx

Head Medical Director

Dr. Garrett Garner, MD, FACOG

Board-certified in Obstetrics and Gynecology and a Fellow of the American College of Obstetricians and Gynecologists.

Professional background